1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) (Echelon Product Code: I-M055 10MG)
| Description: | Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP); and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP); pathway. 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2, 4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent V"V" T-cell activator identified. Provided as the tris-ammonium salt Featured in Publications 1) deBarros, A., M. Chaves-Ferreira, et al. (2011). "CD70"CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human "" peripheral blood lymphocytes." European Journal of Immunology 41(1): 195. 2) Spencer, C. T., G. Abate, et al. (2008). "Only a Subset of Phosphoantigen-Responsive "9"2 T Cells Mediate Protective Tuberculosis Immunity." The Journal of Immunology 181(7): 4471-4484. 3) Moens, E., M. Brouwer, et al. (2011). "IL-23R and TCR signaling drives the generation of neonatal V"9V"2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17." J Leukoc Biol 89(5): 743-52. 4) Hsiao, C.-H. C. and A. J. Wiemer (2018). "A power law function describes the time- and dose-dependency of V"9V"2 T cell activation by phosphoantigens." Biochem Pharmacol 158: 298-304. 5) Rodrigues, N. V., et al. (2018). "Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human V"9V"2 T Cells." Cancer immunology research 6(4): 448-457. 6) Kouakanou, L., et al. (2019). "Vitamin C promotes the proliferation and effector functions of human "" T cells." Cellular & Molecular Immunology. DOI:10.1038/s41423-019-0247-8; |
| Order #: | ECH-I-M055-10MG |
| Unit Size: | 10 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Gel Ice |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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