In Vivo Collagen Hybridizing Peptide Sulfo-Cy7.5 Conjugate, Kit (Echelon Product Code: INVIVOKIT7.5 EaKit)
| Description: | This kit contains 10 doses (24 nmoles) of the Target; and 3 doses (8 nmoles) of the Control; In Vivo Collagen Hybridizing Peptide Sulfo-Cy7.5 Conjugate. The collagen hybridizing peptide (CHP) is a novel and unique peptide that specifically binds unfolded collagen chains, both(in vitro)and(in vivo).[1, 2, 3]By sharing the Gly-X-Y repeating sequence of natural collagen, CHP has a strong capability to hybridize with denatured collagen chains by reforming the triple helical structure, in a fashion similar to DNA fragments annealing to complementary DNA strands. CHP is extremely specific: it has negligible affinity to intact collagen molecules due to lack of binding sites, and it is inert towards non-specific binding because of its neutral and hydrophilic nature. The (in vivo) CHP incorporates our newest sequence which allows them to be directly injected into animals without having to pre-activate them with a heating step. [4]Therefore, the (in vivo) CHPs will always be in their active form and will not self-hybridize once injected. [4]The sCy7.5-CHP is a powerful (in vivo )toolwhich enables straightforward detection of inflammation and tissue damage caused by a large variety of diseases, as well as tissue remodeling during development and aging.[3]CHP can measure and localize mechanical injury to collagenous tissue at the molecular level.[5] The sCy7.5-CHPs are labeled with sulfonated-cyanine 7.5 dye for near-infrared fluorescence (NIRF) detection. This wavelength offers better tissue penetration while minimizing tissue autofluorescence. Specificity:CHP binds to theunfoldedtriple-helical chains ofall collagen types(e.g., I, II, III, IV, etc).[3, 6] Applications:(in vivo imaging, small animal imaging) Features; New sequence designed for (in vivo) use- does not need any pre-activation step unlike CHPs for histology; Near-infrared imaging probe minimizes the chance of autofluorescence in the gut or certain tissues; Can be used for systemic or (in situ )injection; Signal lasts at target sites for days, allowing for imaging at multiple time points with a single dose; High affinity and unparalleled specificity to collagen turnover with essentiallynononspecific binding; Applicable to all types of collagen from all species, relying on collagen's secondary structure instead of any defined sequence for binding; Stable in solution under 4 °C up to three months, eliminating the need to aliquot for storage. |
| Order #: | ECH-INVIVOKIT7.5-EAKIT |
| Unit Size: | Ea Kit |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Gel Ice |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
1,570.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
- Phone: +49 (0)89 3799666-6
- Fax: +49 (0)89 3799666-99
- E-mail: order@biozol.de
- Online Shop: www.mobitec.com
- Phone: +49 (0)89 3799666-6
- E-mail: info@biozol.de
How To Order
Orders can be placed by phone, fax, e-mail, or via our online shop:
MoBiTec is now part of BIOZOL
All orders and requests placed via the online shop on www.mobitec.com are processed by BIOZOL Diagnostica Vertrieb GmbH.
You will receive an order confirmation by fax or e-mail. More information regarding the ordering process can be found here.
Technical Service - Product Information
Viewed