[4-(Decanoylamino)benzyl] phosphonic acid (GWJ-23, GWJ-A-23) (Echelon Product Code: L-3223 5MG)
| Description: | L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (K(i) = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-" levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2). Storage -20°C or below. 1) Tager, A.M. (2012) "Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis" Am. J. Resp. Cell Mol. Biol. 47(5): 563-565. 2) Oikonomou, N, M.A. Mouratis, et al. (2012) "Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis." Am. J. Resp. Cell Mol. Biol. 47(5): 566-574. 3) Jiang, G., D. Madan, et al. (2011). "Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin." Bioorganic & Medicinal Chemistry Letters 21(17): 5098. |
| Order #: | ECH-L-3223-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Gel Ice |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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