GloPIPs BODIPY FL-PI(3, 4, 5)P3, C16 (Echelon Product Code: C-39F16A 50UG)
| Description: | Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3, 4, 5-trisphosphate (PIP3), formed from PI(4, 5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4, 5)P2 and SHIP to PI(3, 4)P2. GloPIPs are labeled at the sn-1 position with BODIPY©-FL (505/513), BODIPY©-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. |
| Order #: | ECH-C-39F16A-50UG |
| Unit Size: | 50 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below, protect from light |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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