Biotin Phosphatidylinositol 4, 5-bisphosphate (Echelon Product Code: C-45B6 50UG)
| Description: | Biotin Phosphatidylinositol 4, 5-bisphosphate is a water soluble analog of PI(4, 5)P2 (PIP2) labeled with biotin at the sn-1 position. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3, 4, 5)P3. Storage -20 °C 1) Rzepecki, P. W. and G. D. Prestwich (2002). "Synthesis of hybrid lipid probes: derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4, 5-bisphosphate (Pea-PIP(2))." J Org Chem 67(16): 5454-60. 2) Goksoy, E., Y.-Q. Ma, et al. (2008). "Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation." Molecular cell 31(1): 124. 3) Michailidis, I., R. Rusinova, et al. (2011). "Phosphatidylinositol-4, 5-bisphosphate regulates epidermal growth factor receptor activation." Pflugers Archiv European Journal of Physiology 461(3): 387. 4) A. L. Egea-Jimenez, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. M. Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau and P. Zimmermann. (2016) "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling" Nat Commun 7, DOI: 10.1038/ncomms12101; |
| Order #: | ECH-C-45B6-50UG |
| Unit Size: | 50 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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