BODIPY FL Phosphatidylinositol 4, 5-bisphosphate (Echelon Product Code: C-45F6 50UG)
| Description: | BODIPY FL Phosphatidylinositol 4, 5-bisphosphate is a water soluble analog of PI(4, 5)P2 (PIP2) labeled with the green fluorophore, Bodipy(©)-FL, at the sn-1 position. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3, 4, 5)P3. Excitation/Emission 503/513 nm Storage -20 °C, protect from light 1) Caromile, L. A., A. Oganesian, et al. (2010). "The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion." J Biol Chem 285(14): 10487-96. 2)Rudge, S. A., D. M. Anderson, et al. (2004). "Vacuole size control: regulation of PtdIns(3, 5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3, 5)P2-specific phosphatase." Mol Biol Cell 15(1): 24-36. 3) Oganesian, A., M. Poot, et al. (2003). "Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation." Proc Natl Acad Sci U S A 100(13): 7563-8. 4) Omar-Hmeadi, M, Gandasi, N, Barg, S (2018). "PtdIns(4, 5)P2 is not required for secretory granule docking" Traffic, DOI:10.1111/tra.12562; |
| Order #: | ECH-C-45F6-50UG |
| Unit Size: | 50 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below, protect from light |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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