1-Stearoyl-2-Arachidonoyl-sn-Glycerol (Echelon Product Code: L-0024 5MG)
| Description: | 1-Stearoyl-2-arachidonoyl-(sn)-glycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-arachidonoyl-(sn)-glycerol is a diacylglycerol is a potent activator of PKC×ñ, PKC×µ, and PKC×ï and also competitively binds to the Ras activator RasGRP. 1, 2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4, 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC), which is a key regulator of signal transduction, cellular regulation, and tumor promotion. » References 1) Lapetina, E.G., Reep, B., Ganong, B.R. & Bell, R.M., (1985), Exogenous sn-1, 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets;", (J. Biol. Chem. )260, 1358-1361. 2) Ganong, B.R., Loomis, C.R., Hannun, Y.A. & Bell, R.M., (1986), Specificity and Mechanism of Protein Kinase C Activation by sn-1, 2-diacylglycerols;", (Proc. Natl. Acad. Sci. USA )83, 1184-1188. |
| Order #: | ECH-L-0024-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Gel Ice |
| Storage: | -80 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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