PI(3, 4)P2 diC16 (ammonium salt) (Echelon Product Code: P-3416A 100UG)
| Description: | PI(3, 4)P2 diC16 (Phosphatidylinositol 3, 4-bisphosphate diC16) ammonium salt is a synthetic dipalmitoyl PI(3, 4)P2. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3, 4-bisphosphate (PI(3, 4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3, 4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. Solubility 70:28:4 CHCl3:MeOH:H2O, 0.5 mg/ml Featured in Publications 1) Dowler, S., R. A. Currie, et al. (1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides." Biochem J 342(Pt 1): 7-12. 2) Karathanassis, D., R. V. Stahelin, et al. (2002). "Binding of the PX domain of p47(phox) to phosphatidylinositol 3, 4- bisphosphate and phosphatidic acid is masked by an intramolecular interaction." Embo J 21(19): 5057-68. 3) Stampoulis, P., T. Ueda, et al. (2012). "Atypical membrane-embedded PI(3, 4)P2 binding site on p47phox PX domain revealed by NMR." J Biol Chem(287): 17848-17859. |
| Order #: | ECH-P-3416A-100UG |
| Unit Size: | 100 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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