PI(4, 5)P2 diC4 (Echelon Product Code: P-4504 1MG)
| Description: | Phosphatidylinositol 4, 5-bisphosphate diC4 (PI(4, 5)P2 diC4) is a synthetic, purified dibutanoyl PI(4, 5)P2. Phosphoinositides (PIP(n)s) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K). Alternate Names: D-myo-Phosphatidylinositol 4, 5-bisphosphate, Dibutanoyl Phosphatidylinositol 4, 5-bisphosphate, PtdIns(4, 5)P2 C4, PI(4, 5)P2 C4, or (4:0/4:0) PIP2 1) Campbell, R. B., F. Liu, et al. (2003). "Allosteric activation of PTEN phosphatase by phosphatidylinositol 4, 5-bisphosphate." J Biol Chem 278(36): 33617-20. 2) Feng, J., M. F. Roberts, et al. (2005). "Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits." Biochemistry 44(7): 2577-84. 3) Luo, R., L. M. Miller Jenkins, et al. (2008). "Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activity." Cellular Signalling 20(11): 1968. 4) Li, Y., M. A. Zaydman, et al. (2011). "KCNE1 enhances phosphatidylinositol 4, 5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity." Proceedings of the National Academy of Sciences 108(22): 9095-9100. 5) A. L. Egea-Jimenez, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. M. Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau and P. Zimmermann. (2016) "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling" Nat Commun 7, DOI: 10.1038/ncomms12101; |
| Order #: | ECH-P-4504-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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