PI(4, 5)P2 diC8 (Echelon Product Code: P-4508 100UG)
| Description: | Phosphatidylinositol 4, 5-bisphosphate diC8 (PI(4, 5)P2 diC8) is a synthetic, purified dioctanoyl PI(4, 5)P2. Phosphoinositides (PIP(n)s) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K). Alternate Names: D-myo-Phosphatidylinositol 4, 5-bisphosphate, Dioctanoyl Phosphatidylinositol 4, 5-bisphosphate, PtdIns(4, 5)P2 C8, PI(4, 5)P2 C8, or PIP2 1) Jenco, J. M., A. Rawlingson, et al. (1998). "Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins." Biochemistry 37(14): 4901-9. 2) Campbell, R. B., F. Liu, et al. (2003). "Allosteric activation of PTEN phosphatase by phosphatidylinositol 4, 5-bisphosphate." J Biol Chem 278(36): 33617-20. 3) Haider, S., A. I. Tarasov, et al. (2007). "Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis." EMBO J 26(16): 3749. 4) Lewis, A. E., L. Sommer, et al. (2011). "Identification of nuclear phosphatidylinositol 4, 5-bisphosphate-interacting proteins by neomycin extraction." Mol Cell Proteomics 10(2): M110 003376. |
| Order #: | ECH-P-4508-100UG |
| Unit Size: | 100 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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