PI(4, 5)P2 diC16 (Echelon Product Code: P-4516 1MG)
| Description: | Phosphatidylinositol 4, 5-bisphosphate diC16 (PI(4, 5)P2 diC16) is a synthetic, purified dipalmitoyl PI(4, 5)P2. Phosphoinositides (PIP(n)s) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K). Alternate Names: Dipalmitoyl Phosphatidylinositol 4, 5-bisphosphate, PtdIns(4, 5)P2 (16:0/16:0), PI(4, 5)P2 C16, or PIP2 1) Hodgkin, M. N., M. R. Masson, et al. (2000). "Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4, 5-biphosphate-specific PH domain." Curr Biol 10(1): 43-6. 2) Ozaki, S., D. B. DeWald, et al. (2000). "Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers." Proc Natl Acad Sci U S A 97(21): 11286-11291. 3) Gwanyanya, A., K. R. Sipido, et al. (2006). "ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes." Am J Physiol Cell Physiol 291(4): C627-35. 4) Liu, Z., T. Klaavuniemi, et al. (2011). "Distinct roles of four gelsolin-like domains of Caenorhabditis elegans gelsolin-like protein-1 in actin filament severing, barbed end capping, and phosphoinositide binding." Biochemistry 49(20): 4349-60. |
| Order #: | ECH-P-4516-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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