PI(5)P diC4 (Echelon Product Code: P-5004 1MG)
| Description: | Phosphatidylinositol 5-phosphate diC4 (PI(5)P diC4) is a synthetic, purified dibutanoyl PI(5)P. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4, 5)P2 by Type II PIP kinases. Alternate Names: D-myo-Phosphatidylinositol 5-phosphate, Dibutanoyl Phosphatidylinositol 5-phosphate, PtdIns(5)P C4, PI(5)P C4, or PI5P 1) Guo, J., M. R. Wenk, et al. (2003). "Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles." Proc Natl Acad Sci U S A 100(7): 3995-4000. 2) Pendaries, C., H. Tronchere, et al. (2006). "PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection." Embo J 25(5): 1024-34. 3) Ramel, D., F. Lagarrigue, et al. (2011). "Shigella flexneri Infection Generates the Lipid PI5P to Alter Endocytosis and Prevent Termination of EGFR Signaling." Sci. Signal. 4(191): ra61-. 4) Boal, F. d. r., A. Puhar, et al. (2016). "PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment." Cell Reports., doi:10.1016/j.celrep.2015.12.079; |
| Order #: | ECH-P-5004-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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