PI(5)P diC16 (Echelon Product Code: P-5016 1MG)
| Description: | Phosphatidylinositol 5-phosphate diC16 (PI(5)P diC16) is a synthetic, purified dipalmitoyl PI(5)P. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4, 5)P2 by Type II PIP kinases. Alternate Names: D-myo-Phosphatidylinositol 5-phosphate, Dipalmitoyl Phosphatidylinositol 5-phosphate, PtdIns(5)P C16, PI(5)P C16, or PI5P 1) Barylko, B., S. H. Gerber, et al. (2001). "A Novel Family of Phosphatidylinositol 4-Kinases Conserved from Yeast to Humans." J Biol Chem 276(11): 7705-7708. 2) Sbrissa, D., O. C. Ikonomov, et al. (2004). "Role for a Novel Signaling Intermediate, Phosphatidylinositol 5-Phosphate, in Insulin-Regulated F-Actin Stress Fiber Breakdown and GLUT4 Translocation." Endocrinology 145(11): 4853-4865. 3) Grainger, D., C. Tavelis, et al. (2011). "Involvement of phosphatidylinositol 5-phosphate in insulin-stimulated glucose uptake in the L6 myotube model of skeletal muscle." Pflugers Archiv European Journal of Physiology 462(5): 723-732. 4) Bua, D.J., Martin, G.M. et al. (2013). "Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage." Sci. Rep.3: 2137. 5) Sumita, K., Y.-H. Lo, et al. (2016). "The Lipid Kinase PI5P4Kb Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis." Molecular Cell. DOI:10.1016/j.molcel.2015.12.011; |
| Order #: | ECH-P-5016-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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