S1P Fluorescein (Echelon Product Code: S-200F 50UG)
| Description: | Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid formed by phosphorylation of sphingosine by sphingosine kinases. S1P binds to five G-protein coupled receptors designated S1P(1-5) leading to cell proliferation, motility, and has a role in regulation cell shape. In addition, S1P acts as an intracellular mediator in a receptor-independent manner regulating cell survival and Ca(2+) homeostasis. Sphingosine 1-phosphate fluorescein is a S1P analog with natural erythro stereochemistry labeled at the terminus of the alkyl chain with fluorescein. Excitation/Emission: 494/521 nm Featured in Publications 1) Peest, U., S. C. Sensken, et al. (2008). "S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake." J Cell Biochem 104(3): 756-72. 2) Meissner, A., J. Yang, et al. (2012). "Tumor Necrosis Factor-"-Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure." Circulation 125(22): 2739-2750. 3) Dickinson, A. J., et al. (2015). "Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood." u Integrative Biology /u 7(4): 392-401. 4) Vogt, K., et al. (2018). "Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins." Thromb Haemost 118(01): 132-142. |
| Order #: | ECH-S-200F-50UG |
| Unit Size: | 50 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice Or Gel Ice Depending On Destination |
| Storage: | -20 °C or below |
| Subcategory: | Lipids |
| More information: | Go to webpage |
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