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APPBP1/6xHis-UBA3 (UBPBio Product Code: B1400)

APPBP1/6xHis-UBA3 (UBPBio Product Code: B1400)
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Description: APPBP1/UBA3 is the heterodimeric E1 enzyme that conjugates Nedd8 to protein substrates. Nedd8 is conjugated onto the catalytic cysteine residue of UBA3 by formation of a thioester bond in an ATP-dependent reaction. The activated Nedd8 is then passed on to an E2 (Ubc12) to be finally attached to a substrate. Nedd8 is mainly conjugated on Cullins to increase the activity of the Cullin – RING E3 Ub ligases.
Order #: UBP-B1400-25
Unit Size: 25 µg
Supplier: UBPBio
Restrictions: Only available in selected countries.
Shipping: Dry ice
Storage: -80 °C
Subcategory: E1 Activating Enzymes
More information: Go to webpage
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223.00 € *

*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).

Delivery time approx. 8 - 10 working days

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