ITCH (UBPBio Product Code: K1400)

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Description:	ITCH, also called atrophin-1 interacting protein 4 (AIP4), is a HECT-type E3 ubiquitin ligase. It contains an N-terminal Ca-dependent phospholipid-binding C2 domain, four WW domains, and a C-terminal HECT domain. Mice deficient in ITCH protein display many autoimmune-like disease characteristics such as lymphoproliferation in the spleen and lymph nodes. More than a dozen of substrates of ITCH have been identified including p63, p73 and Notch1. The ligase may be responsible for ubiquitinating proteins with K29-, K48-, and/or K63-linked ubiquitin chains.
Order #:	UBP-K1400-50
Unit Size:	50 µg
Supplier:	UBPBio
Restrictions:	Only available in selected countries.
Shipping:	Dry ice
Storage:	-80 °C
Subcategory:	E3 Ubiquitin Ligases
More information:	Go to webpage

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