[Ala13]-Apelin-13 - 1 mg
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| Description: | Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77). Apelin -13 is a vasoactive peptide and one of the most potent endogenous inotropic agents known. It is one of the active peptide fragments resulting from maturation of preproapelin. It is suggested that Apelin-13 could be a competitive agonist to the apelin receptor, which is a class A G-protein coupled receptor and is a putative target for treatment of cardiovascular and metabolic diseases. Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue. |
| Order #: | ASP-AS-61078 |
| Unit Size: | 1 mg |
| Supplier: | AnaSpec |
| Restrictions: | Only available in Germany and selected European countries. |
| Shipping: | RT |
| Storage: | - 20 °C |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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