Fibrinogen gamma-Chain (377-395) - 1 mg
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| Description: | Activation of the coagulation cascade converts fibrinogen to fibrin, through binding of an epitope in the fibrinogen γ chain (γ377–395) to CD11b/CD18 integrin (Mac-1). In the central nervous system, fibrinogen has been associated to demyelination and microglial activation, while this peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Since blocking fibrinogen–Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma-fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation. |
| Order #: | ASP-AS-62128 |
| Unit Size: | 1 mg |
| Supplier: | AnaSpec |
| Restrictions: | Only available in Germany and selected European countries. |
| Shipping: | RT |
| Storage: | - 20 °C |
| Subcategory: | Peptides |
| More information: | Go to webpage |
185.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
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- Phone: +49 (0)89 3799666-6
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