Endothelin 1, human (Echelon Product Code: 331-25 1MG)
| Description: | CAS Number: 117399-94-7 Molecular Weight: 2491.9 Salt Form: Acetate Purity: 98% Sequence (3-letter): Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Cys1-15, Cys3-11) Sequence (1-letter): CSCSSLMDKECVYFCHLDIIW-OH (C1-15, C3-11) Storage: -20 °C or below Solubility: 1 mg/ml in water Endothelin-1 is one of three isoforms of human endothelin (ET-1). It is a potent vasoconstrictor that is expressed by many cell types, with the vascular endothelium being most prominent. ET-1 is also produced by many tissues, including kidney, brain and lung among others. Antagonists of ET-1 receptors are used to treat pulmonary hypertension by inhibiting pulmonary vascular constriction thereby decreasing pulmonary vascular resistance. » References 1. Sanchez, O. et al. (2006) "Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension" Chest 130 (1): 182-189; 2. Mubarak, K.K. (2010) "A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension" Respir. Med. 104 (1): 9-21; 3.Fellner, S.K. and Arendshorst, W.J. (2004) "Endothelin A and B receptors of preglomerular vascular smooth muscle cells" Kidney International, 65: 1810"1817. |
| Order #: | ECH-331-25-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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