Apamin, bee venom (SS1-11, SS3-15) (Echelon Product Code: 425-10 0.5MG)
| Description: | CAS Number: 24345-16-2 Molecular Weight: 2029.93 Salt Form: Acetate Purity: 96% Sequence (3-letter): Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15) Sequence (1-letter): CNCKAPETALCARRCQQH-NH2 Storage: -20 °C or below Solubility: water to 1 mg/mL Apamin is a peptide toxin found in bee venom that is known to cross the blood-brain barrier. Apamin potently blocks ATP-type Ca+2-activated K+ channels SK1, SK2 and SK3 (low nM to sub-nM IC50), but is inactive against SK4. Apamin is used to elucidate the roles of SK channels in neurons and some cancer cells. It is a globular peptide with disulfide bridges between Cys1-Cys11 (SS1-11) and Cys3-Cys15 (SS3-15). » References 1. Blatz, A.L. and Magleby, K.L. (1986) "Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle" Nature 323: 718 " 720. 2. a Burnham, M.P. et al. (2002) "Characterization of an apamin-sensitive small-conductance Ca2+-activated K+ channel in porcine coronary artery endothelium: relevance to EDHF" Br. J. Pharmacol. 135 (5): 1133"1143. |
| Order #: | ECH-425-10-0.5MG |
| Unit Size: | 0.5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
197.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
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