Beta Amyloid (1-42), human (Echelon Product Code: 641-15 5MG)
| Description: | CAS Number: 107761-42-2 Molecular Weight: 4511.3 Salt Form: TFA Purity: 95% Sequence (3-letter): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH Sequence (1-letter): DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH Storage: -20 °C or below Solubility: 1 mg/mL in 50 mM Tris or dissolve 1 mg in 70-80 uL 1% NH4OH then dilute to 1 mg/mL with 1X PBS. Do not store in 1% NH4OH, dilute immediately with PBS. Beta amyloid (1-42) is the predominant form of "-amyloid protein found in the brains of patients with Alzheimer"s disease and Down"s syndrome. Beta amyloid down-regulates bcl-2 (a key anti-apoptotic protein) and upregulates bax (cell death promoter) with evidence suggesting that it renders neurons vulnerable to age-dependent stress and neurodegeneration » References; 1. Scheuner, D. et al (1996) "Secreted amyloid bold beta"protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease" Nat. Med. 2: 864 " 870. 2. Lacor, P. N. et al (2004) "Synaptic Targeting by Alzheimer's-Related Amyloid " Oligomers" J. Neurosci. 24 (45): 10191-10200. 3.Paradis et al (1996) "Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons" J. Neurosci. 16: 7533. |
| Order #: | ECH-641-15-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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