Furin Inhibitor II (Hexa-D-Arginine) (Echelon Product Code: 855-10 1MG)
| Description: | CAS Number: 673202-67-0 Molecular Weight: 953.63 Salt Form: TFA Purity: 96% Sequence (3-letter): D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 Sequence (1-letter): rrrrrr-NH2 Storage: -20 °C or below Solubility: 20% acetonitrile/water 1 mg/mL Furin inhibitor II (Hexa-D-Arginine), as the name implies, inhibits furin (Ki = 106 nM for purified furin). Furin is an enzyme belonging to the subtilisin-like proprotein convertase family which process precursor proteins into biologically active products. Representative substrates include von Willebrand factor, TGF"-1 precursor, MMP-1, gp160, proparathyroid hormone and proalbumin. Peptide contains all D-amino acids; also called Hexa-D-Arg or Hexa-D-Arginine or (D-Arg)6-NH2 Results from a recent paper; and preprint; show the presence of a furin cleavage site on the spike protein of the SARS-CoV-2 which is required for membrane fusion and replication. Inhibition of furin activity can stop viral replication. » References 1. Cameron, A. et al. (2000) "Polyarginines Are Potent Furin Inhibitors" J. Biol. Chem. 275: 36741-36749. 2. Henrich, S. et al. (2005) "Proprotein Convertase Models based on the Crystal Structures of Furin and Kexin: Explanation of their Specificity" J. Mol. Biol. 345 (2): 211"227. |
| Order #: | ECH-855-10-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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