Ac-Asp-Glu-Val-Asp-pNA (Caspase-3 (Apopain) Substrate) (Echelon Product Code: 860-20 25MG)
| Description: | CAS Number: 189950-66-1 Molecular Weight: 638.22 Salt Form: TFA Purity: 96% Sequence (3-letter): Ac-Asp-Glu-Val-Asp-pNA Sequence (1-letter): Ac-DEVD-pNA Storage: -20 °C or below Solubility: DMSO and acetonitrile:methanol (1:1) to 1 mg/ml Caspase-3 (Apopain) Substrate is a colorimetric substrate for caspase-3 with the sequence Ac-DEVD-pNA. Caspase-3 is a protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Cleavage of Ac-DEVD-pNA is monitored by measuring absorbance at 405 nm. Ac-DEVD-pNA is poorly cleaved by caspase-2. Km = 18 µM (Casp-1), 11 µM (Casp-3), 32 µM (Casp-4), 180 µM (Casp-6), 12 µM (Casp-7) » References 1. Talanian, R.V. et al. (1997) "Substrate Specificities of Caspase Family Proteases" J. Biol. Chem. 272 (15): 9677"9682. 2.Nagane, M. et al. (1998) "Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases" Proc. Natl. Acad. Sci. USA 95 (10): 5724"5729. |
| Order #: | ECH-860-20-25MG |
| Unit Size: | 25 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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