Ac-Asp-Met-Gln-Asp-AMC (Caspase 3 (Apopain) Substrate) (Echelon Product Code: 860-28 5MG)
| Description: | CAS Number: 355137-38-1 Molecular Weight: 706.23 Salt Form: TFA Purity: 96% Sequence (3-letter): Ac-Asp-Met-Gln-Asp-AMC Sequence (1-letter): Ac-DMQD-AMC Storage: -20 °C or below Ac-Asp-Met-Gln-Asp-AMC is a fluorogenic substrate for Caspase 3 (Apopain). Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer"s disease and proposed as a target for drug discovery. Ac-DMQD-AMC is reported to be a more specific caspase-3 substrate than Ac-DEVD-AMC. Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm. » References 1. Talanian, R.V. et al. (1997) "Substrate Specificities of Caspase Family Proteases" J. Biol. Chem. 272 (15): 9677"9682. 2.Nagane, M. et al. (1998) "Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases" Proc. Natl. Acad. Sci. USA 95 (10): 5724"5729. 3) Troy T. Rohn, Elizabeth Head "Caspases as Therapeutic Targets in Alzheimer"s Disease: Is It Time to "Cut" to the Chase"" Int J Clin Exp Pathol. 2009; 2(2): 108"118. |
| Order #: | ECH-860-28-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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