Ac-Asp-Met-Gln-Asp-AFC (Caspase 3 Substrate) (Echelon Product Code: 860-30 5MG)
| Description: | Molecular Weight: 760 Salt Form: N/A Purity: 95% Sequence (3-letter): Ac-Asp-Met-Gln-Asp-AFC Sequence (1-letter): Ac-DMQD-AFC Storage: -20 °C or below Ac-Asp-Met-Gln-Asp-AFC is a fluorogenic substrate for Caspase 3 (Apopain). Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer"s disease and proposed as a target for drug discovery. Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm. » References 1. Talanian, R.V. et al. (1997) "Substrate Specificities of Caspase Family Proteases" J. Biol. Chem. 272 (15): 9677"9682. 2.Nagane, M. et al. (1998) "Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases" Proc. Natl. Acad. Sci. USA 95 (10): 5724"5729. 3) Troy T. Rohn, Elizabeth Head "Caspases as Therapeutic Targets in Alzheimer"s Disease: Is It Time to "Cut" to the Chase"" Int J Clin Exp Pathol. 2009; 2(2): 108"118. |
| Order #: | ECH-860-30-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
Add to request list
- Phone: +49 (0)89 3799666-6
- E-mail: info@biozol.de
MoBiTec is now part of BIOZOL
All orders and requests placed via the online shop on www.mobitec.com are processed by BIOZOL Diagnostica Vertrieb GmbH.
You will receive an order confirmation by fax or e-mail. More information regarding the ordering process can be found here.
Technical Service - Product Information
Viewed