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Ac-Val-Glu-Ile-Asp-AMC (Caspase 6 (Mch2) Substrate) (Echelon Product Code: 860-52 25MG)

Ac-Val-Glu-Ile-Asp-AMC (Caspase 6 (Mch2) Substrate) (Echelon Product Code: 860-52 25MG)
Description: CAS Number: 219137-97-0 Molecular Weight: 673.72 Salt Form: N/A Purity: 96% Sequence (3-letter): Ac-Val-Glu-Ile-Asp-AMC Sequence (1-letter): Ac-VEID-AMC Storage: -20 °C or below Solubility: DMSO, phosphate buffer pH 7.5 Ac-VEID-AMC is a fluorogenic substrate for caspase 6 (Mch-2"), a member of the cysteine-aspartate protease family, which play a central role in the execution-phase of apoptosis. The excitation/emission maximum of AMC is 340-360/440-460 nm, respectively. Ac-VEID-AMC is based on lamin A site of cleavage. » References 1. Benford, H.L. et al. (2001) "Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro" 28 (5): 465"473. 2. Rouaux, C. e al. (2003) "Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration" EMBO J. 22 (24): 6537"6549.
Order #: ECH-860-52-25MG
Unit Size: 25 mg
Supplier: Echelon Biosciences
Restrictions: Available in all European countries, except France & Italy.
Shipping: Room Temperature
Storage: -20 °C or below
Subcategory: Peptides
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