Ac-Trp-Glu-His-Asp-pNA (Caspase 1 Substrate) (Echelon Product Code: 861-66 5MG)
| Description: | Molecular Weight: 747.27 Salt Form: N/A Purity: 96% Sequence (3-letter): Ac-Trp-Glu-His-Asp-pNA Sequence (1-letter): Ac-WEHD-pNA Storage: -20 °C or below Ac-Trp-Glu-His-Asp-pNA is a colorimetric substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that preferentially cleaves substrates built on VAD (val-ala-asp) or WEAD (trp-glu-ala-asp) sequences. Ac-WEHD-pNA will also act as a substrate for caspase 4, caspase 5 and caspase 14. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm. |
| Order #: | ECH-861-66-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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