Ac-DEVD-AFC, (Caspase 3 (Apopain) Substrate) (Echelon Product Code: 863-17 5MG)
| Description: | CAS Number: 201608-14-2 Molecular Weight: 729.21 Salt Form: N/A Purity: 96% Sequence (3-letter): Ac-Asp-Glu-Val-Asp-AFC Sequence (1-letter): Ac-DEVD-AFC Storage: -20 °C or below Solubility: 50% acetic acid in water (5 mg/ml), DMF, DMSO, methanol, and slightly soluble in water (0.4 mg/ml). Ac-DEVD-AFC is a fluorogenic substrate for caspase-3. Caspase-3 is a protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Cleavage of Ac-DEVD-AFC is monitored by measuring an increase in fluorescence signal due to AFC cleavage. The excitation and emission maxima for AFC are 400 nm and 505 nm, respectively. » References 1.Cardone, M.H. et al. (1998) "Regulation of Cell Death Protease Caspase-9 by Phosphorylation" Nature 282 (5392): 1318-1321. 2. Deveraux, Q.L. et al. (1997) "X-linked IAP is a direct inhibitor of cell-death proteases" Nature 388: 300-304. |
| Order #: | ECH-863-17-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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