Ac-Val-Asp-Val-Ala-Asp-AFC (Caspase 2 (ICH-1) Substrate) (Echelon Product Code: 863-48 5MG)
| Description: | CAS Number: 219137-85-6 Molecular Weight: 770.27 Salt Form: N/A Purity: 96% Sequence (3-letter): Ac-Val-Asp-Val-Ala-Asp-AFC Sequence (1-letter): Ac-VDVAD-AFC Storage: -20 °C or below Ac-Val-Asp-Val-Ala-Asp-AFC is a fluorogenic substrate for caspase 2. Caspase 2, part of the ICH-1 sub-family, is a cysteine protease with a poorly defined role in apoptosis. It associates with several apoptotic proteins such as death effector filament-forming Ced-4-like apoptosis protein (DEFCAP), RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD), and apoptosis repressor with caspase recruitment domain (ARC). Caspase 2 can be activated by the PIDDosome formed by the association of PIDD1 and CRADD. Recent work demonstrates that Caspase-2 resides in the mitochondria and is essential for stress-induced apoptosis. Caspase-2 cleaves at an Asp residue with a preferred sequence of Val-Asp-Val-Ala-Asp-X. Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm. |
| Order #: | ECH-863-48-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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