Ac-Trp-Glu-His-Asp-AFC (Caspase 1 Substrate) (Echelon Product Code: 863-63 5MG)
| Description: | Molecular Weight: 838.76 Salt Form: N/A Purity: 96% Sequence (3-letter): Ac-Trp-Glu-His-Asp-AFC Sequence (1-letter): Ac-WEHD-AFC Storage: -20 °C or below Ac-WEHD-AFC is a fluorogenic substrate for caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that preferentially cleaves substrates built on VAD (val-ala-asp) or WEAD (trp-glu-ala-asp) sequences. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm. |
| Order #: | ECH-863-63-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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