Ac-Ala-Glu-Val-Asp-AFC (Caspase 3 Substrate) (Echelon Product Code: 863-65 25MG)
| Description: | Molecular Weight: 685.22 Salt Form: N/A Purity: 96% Sequence (3-letter): Ac-Ala-Glu-Val-Asp-AFC Sequence (1-letter): Ac-AEVD-AFC Storage: -20 °C or below Ac-AEVD-AFC is a fluorogenic substrate for caspase 3. Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9, and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer"s disease and proposed as a target for drug discovery. Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm. |
| Order #: | ECH-863-65-25MG |
| Unit Size: | 25 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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