Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH (Caspase 1 Substrate) (Echelon Product Code: 865-21 1MG)
| Description: | CAS Number: 189696-01-3 Molecular Weight: 1144.43 Salt Form: N/A Purity: 96% Sequence (3-letter): Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH Sequence (1-letter): (Mca)YVADAP(Lys(DNP))-OH Storage: -20 °C or below Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH is a FRET substrate for caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that preferentially cleaves substrates built on VAD (val-ala-asp) or WEAD (trp-glu-ala-asp) sequences. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. Activity can be continuously measured by excitation at 325nm and emission at 392 nm |
| Order #: | ECH-865-21-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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