Z-Arg-Arg-AMC (Cathepsin B substrate) (Echelon Product Code: 866-30 10MG)
| Description: | CAS Number: 88937-61-5 Molecular Weight: 621.3 Salt Form: HCl Purity: 96% Sequence (3-letter): Z-Arg-Arg-AMC Sequence (1-letter): Z-RR-AMC Storage: -20 °C or below Z-RR-AMC is a fluorogenic substrate for Cathepsin B. Cathepsin B is a lysosomal cysteine protease with a role in intracellular protein degradation. Cathepsin B crosses the blood-brain barrier and elevated levels are implicated in many neurological maladies including traumatic brain injury, epilepsy, and Alzheimer's disease. Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm. » References 1) Hulkower KI, Butler CC, Linebaugh BE, Klaus JL, Keppler D, Giranda VL, Sloane BF. Fluorescent microplate assay for cancer cell-associated cathepsin B. Eur J Biochem. 2000 Jul;267(13):4165-70. doi: 10.1046/j.1432-1327.2000.01458.x; |
| Order #: | ECH-866-30-10MG |
| Unit Size: | 10 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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