Z-Val-Phe-CHO (Calpain Inhibitor III) (Echelon Product Code: 870-50 10MG)
| Description: | CAS Number: 88191-84-8 Molecular Weight: 382.46 Salt Form: N/A Purity: 96% Sequence (3-letter): Z-Val-Phe-CHO, Z-Val-Phe-H Sequence (1-letter): Z-VF-CHO Storage: -20 °C or below Solubility: DMSO to 25 mg/mL Calpain Inhibitor III is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) in addition to cathepsin B (Ki = 24 nM). Calpains are calcium-dependent cysteine proteases involved in a wide range of physiological processes. Calpain inhibitors can protect against necrotic neuronal death and, to a lesser extent, apoptotic death. Calpain inhibitors are useful tools for studying diseases, especially those involving neurodegeneration. Calpain Inhibitor III has been shown to inhibit neurofilament degradation in neurodegenerative diseases. » References 1.Wang, K.K. et al. (1996) "An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable Calpain inhibitor and is neuroprotective" Proc. Natl. Acad. Sci. USA 93 (13): 6687-6692; 2.Wang, K.K. (2000) "Calpain and caspase: can you tell the difference"" Trends Neurosci. 23 (1): 20-26; 3.Kunz, S et al. (2004) "The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia" Pain 110 (1-2): 409-18. |
| Order #: | ECH-870-50-10MG |
| Unit Size: | 10 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
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