Ac-Arg-Gly-Phe-Phe-Pro-AMC (Echelon Product Code: 877-06 5MG)
| Description: | Molecular Weight: 821.94 Salt Form: TFA Purity: 96% Sequence (3-letter): Ac-Arg-Gly-Phe-Phe-Pro-AMC Sequence (1-letter): Ac-RGFFP-AMC Storage: -20 °C or below Ac-Arg-Gly-Phe-Phe-Pro-AMC is a fluorogenic substrate suitable for the assay of cathepsin D. Cathepsin D cleaves the Phe-Phe bond and the resulting RP-AMC dipeptide can be cleaved by dipeptidyl peptidase IV (DPP IV) resulting in a fluorescent signal. Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm. Cathepsin D is a lysosomal aspartyl protease whose role is to degrade and activate intracellular proteins including hormones, enzyme precursors, and growth factors. Over expression in tumors stimulates metastasis and considered a marker of poor prognosis in breast cancer. |
| Order #: | ECH-877-06-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Peptides |
| More information: | Go to webpage |
236.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
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