ONX-0914 (PR-957) (UBPBio Product Code: F1411)
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| Description: | ONX-0914, also known as PR-957, is a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. ONX-0914 selectively inhibits low-molecular mass polypeptide-7 (LMP7), the subunit specific for the immunoproteasome that catalyzes the chymotyrpsion-like activity, with an IC50 < 100 nM. Cell culture and animal studies have shown that ONX-0914 blocks the production of proinflammatory cytokines including interleukin-6 and 17, indicating that it has potential uses in the treatment of some autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease and lupus. Dose: 0.1-0.5 μM for in vitro or cell couture assays; intravenous or subcutaneous administration at 2-10 mg/Kg daily for 5-7 days for animal studies. |
| Order #: | UBP-F1411-25 |
| Unit Size: | 25 mg |
| Supplier: | UBPBio |
| Restrictions: | Only available in selected countries. |
| Shipping: | Ambient temp. |
| Storage: | -20 °C |
| Subcategory: | Proteasome / Deubiquitinase Inhibitors |
| More information: | Go to webpage |
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