ML323 (UBPBio Product Code: F4121)
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| Description: | ML323 is a cell permealbe, selective and highly potent inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. ML 323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting USP1-UAF1. ML323 was used at 10-30 µM in various in vitro assay. |
| Order #: | UBP-F4121-25 |
| Unit Size: | 25 mg |
| Supplier: | UBPBio |
| Restrictions: | Only available in selected countries. |
| Shipping: | Ambient temp. |
| Storage: | -20 °C |
| Subcategory: | Proteasome / Deubiquitinase Inhibitors |
| More information: | Go to webpage |
495.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
- Phone: +49 (0)89 3799666-6
- Fax: +49 (0)89 3799666-99
- E-mail: order@biozol.de
- Online Shop: www.mobitec.com
- Phone: +49 (0)89 3799666-6
- E-mail: info@biozol.de
How To Order
Orders can be placed by phone, fax, e-mail, or via our online shop:
MoBiTec is now part of BIOZOL
All orders and requests placed via the online shop on www.mobitec.com are processed by BIOZOL Diagnostica Vertrieb GmbH.
You will receive an order confirmation by fax or e-mail. More information regarding the ordering process can be found here.
Technical Service - Product Information
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