Description: | UMI-77 is a selective Mcl-1 inhibitor by binding of the BH3-binding groove of Mcl-1, by which it blocks the interactions of Bax/Mcl-1 and Bak/Mcl-1. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induces apoptosis of various pancreatic cancer cell lines. |
Order #: | UBP-F7151-25 |
Unit Size: | 25 mg |
Supplier: | UBPBio |
Restrictions: | Only available in selected countries. |
Shipping: | Ambient temp. |
Storage: | -20 °C |
Subcategory: | Proteasome / Deubiquitinase Inhibitors |
More information: | Go to webpage |
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